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Page 1
The bone marrow microenvironment at single-cell resolution.
Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I. Tikhonova AN, et al. Nature. 2019 May;569(7755):222-228. doi: 10.1038/s41586-019-1104-8. Epub 2019 Apr 10. Nature. 2019. PMID: 30971824 Free PMC article.
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I. Witkowski MT, et al. Cancer Cell. 2020 Jun 8;37(6):867-882.e12. doi: 10.1016/j.ccell.2020.04.015. Epub 2020 May 28. Cancer Cell. 2020. PMID: 32470390 Free PMC article.
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E. Hanniford D, et al. Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007. Cancer Cell. 2020. PMID: 31935372 Free PMC article.
Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Glytsou C, Chen X, Zacharioudakis E, Al-Santli W, Zhou H, Nadorp B, Lee S, Lasry A, Sun Z, Papaioannou D, Cammer M, Wang K, Zal T, Zal MA, Carter BZ, Ishizawa J, Tibes R, Tsirigos A, Andreeff M, Gavathiotis E, Aifantis I. Glytsou C, et al. Cancer Discov. 2023 Jul 7;13(7):1656-1677. doi: 10.1158/2159-8290.CD-22-0601. Cancer Discov. 2023. PMID: 37088914 Free PMC article.
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC, Pacold ME. Ngo B, et al. Cancer Discov. 2020 Sep;10(9):1352-1373. doi: 10.1158/2159-8290.CD-19-1228. Epub 2020 Jun 22. Cancer Discov. 2020. PMID: 32571778 Free PMC article.
Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ.
Koscsó B, Kurapati S, Rodrigues RR, Nedjic J, Gowda K, Shin C, Soni C, Ashraf AZ, Purushothaman I, Palisoc M, Xu S, Sun H, Chodisetti SB, Lin E, Mack M, Kawasawa YI, He P, Rahman ZSM, Aifantis I, Shulzhenko N, Morgun A, Bogunovic M. Koscsó B, et al. Sci Immunol. 2020 Apr 10;5(46):eaax0062. doi: 10.1126/sciimmunol.aax0062. Sci Immunol. 2020. PMID: 32276965 Free PMC article.
Immune-Based Therapies in Acute Leukemia.
Witkowski MT, Lasry A, Carroll WL, Aifantis I. Witkowski MT, et al. Trends Cancer. 2019 Oct;5(10):604-618. doi: 10.1016/j.trecan.2019.07.009. Epub 2019 Aug 29. Trends Cancer. 2019. PMID: 31706508 Free PMC article. Review.
Cell-by-Cell Deconstruction of Stem Cell Niches.
Tikhonova AN, Lasry A, Austin R, Aifantis I. Tikhonova AN, et al. Cell Stem Cell. 2020 Jul 2;27(1):19-34. doi: 10.1016/j.stem.2020.06.013. Cell Stem Cell. 2020. PMID: 32619515 Free PMC article. Review.
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