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Immune checkpoint blockade: timing is everything.
Sinicrope FA, Turk MJ. Sinicrope FA, et al. J Immunother Cancer. 2024 Aug 28;12(8):e009722. doi: 10.1136/jitc-2024-009722. J Immunother Cancer. 2024. PMID: 39209456 Free PMC article. Review.
Depletion of conventional CD4+ T cells is required for robust priming and dissemination of tumor antigen-specific CD8+ T cells in the setting of anti-CD4 therapy.
Ramirez DE, Dragnev CPC, Searles TG, Spicer N, Chen T, Lines JL, Hawkes AR, Davis WL, Mohamed A, Shirai K, Phillips JD, Rosato PC, Huang YH, Turk MJ. Ramirez DE, et al. J Immunother Cancer. 2024 Nov 9;12(11):e010170. doi: 10.1136/jitc-2024-010170. J Immunother Cancer. 2024. PMID: 39521617 Free PMC article.