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Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma.
Wang J, Ferrena A, Zhang R, Singh S, Viscarret V, Al-Harden W, Aldahamsheh O, Borjihan H, Singla A, Yaguare S, Tingling J, Zi X, Lo Y, Gorlick R, Schwartz EL, Zhao H, Yang R, Geller DS, Zheng D, Hoang BH. Wang J, et al. Oncogene. 2024 Mar;43(13):962-975. doi: 10.1038/s41388-024-02942-4. Epub 2024 Feb 14. Oncogene. 2024. PMID: 38355807 Free PMC article.
SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
Ferrena A, Wang J, Zhang R, Karadal-Ferrena B, Al-Hardan W, Singh S, Borjihan H, Schwartz EL, Zhao H, Oktay MH, Yang R, Geller DS, Hoang BH, Zheng D. Ferrena A, et al. Mol Cancer Ther. 2024 Feb 1;23(2):223-234. doi: 10.1158/1535-7163.MCT-23-0173. Mol Cancer Ther. 2024. PMID: 37871911 Free PMC article.
Novel candidate metastasis-associated genes for synovial sarcoma.
Zhao Z, Niu J, Wang J, Zhang R, Liang H, Ma Y, Ferrena A, Wang W, Yang R, Geller DS, Guo W, Ren T, Hoang BH, Tang X, Yan T. Zhao Z, et al. J Cell Mol Med. 2024 Jul;28(14):e18541. doi: 10.1111/jcmm.18541. J Cell Mol Med. 2024. PMID: 39046429 Free PMC article.
Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways.
Ferrena A, Zhang R, Wang J, Zheng XY, Göker B, Borjihan H, Chae SS, Lo Y, Zhao H, Schwartz E, Loeb D, Yang R, Geller D, Zheng D, Hoang B. Ferrena A, et al. bioRxiv [Preprint]. 2024 Jun 6:2024.06.04.597347. doi: 10.1101/2024.06.04.597347. bioRxiv. 2024. PMID: 38895216 Free PMC article. Preprint.
SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis.
Ferrena A, Wang J, Zhang R, Karadal-Ferrena B, Al-Hardan W, Singh S, Borjihan H, Schwartz E, Zhao H, Yang R, Geller D, Hoang B, Zheng D. Ferrena A, et al. bioRxiv [Preprint]. 2023 May 12:2023.05.09.540053. doi: 10.1101/2023.05.09.540053. bioRxiv. 2023. Update in: Mol Cancer Ther. 2024 Feb 1;23(2):223-234. doi: 10.1158/1535-7163.MCT-23-0173 PMID: 37214958 Free PMC article. Updated. Preprint.