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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity.
Liu X, Hogg GD, Zuo C, Borcherding NC, Baer JM, Lander VE, Kang LI, Knolhoff BL, Ahmad F, Osterhout RE, Galkin AV, Bruey JM, Carter LL, Mpoy C, Vij KR, Fields RC, Schwarz JK, Park H, Gupta V, DeNardo DG. Liu X, et al. Cancer Cell. 2023 Jun 12;41(6):1073-1090.e12. doi: 10.1016/j.ccell.2023.04.018. Epub 2023 May 25. Cancer Cell. 2023. PMID: 37236195 Free PMC article.
Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression.
Ye J, Baer JM, Faget DV, Morikis VA, Ren Q, Melam A, Delgado AP, Luo X, Bagchi SM, Belle JI, Campos E, Friedman M, Veis DJ, Knudsen ES, Witkiewicz AK, Powers S, Longmore GD, DeNardo DG, Stewart SA. Ye J, et al. Cancer Discov. 2024 Jul 1;14(7):1302-1323. doi: 10.1158/2159-8290.CD-23-0426. Cancer Discov. 2024. PMID: 38683161 Free PMC article.
Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC.
Baer JM, Zuo C, Kang LI, de la Lastra AA, Borcherding NC, Knolhoff BL, Bogner SJ, Zhu Y, Yang L, Laurent J, Lewis MA, Zhang N, Kim KW, Fields RC, Yokoyama WM, Mills JC, Ding L, Randolph GJ, DeNardo DG. Baer JM, et al. Nat Immunol. 2023 Sep;24(9):1443-1457. doi: 10.1038/s41590-023-01579-x. Epub 2023 Aug 10. Nat Immunol. 2023. PMID: 37563309 Free PMC article.
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy.
Zuo C, Baer JM, Knolhoff BL, Belle JI, Liu X, Alarcon De La Lastra A, Fu C, Hogg GD, Kingston NL, Breden MA, Dodhiawala PB, Zhou DC, Lander VE, James CA, Ding L, Lim KH, Fields RC, Hawkins WG, Weber JD, Zhao G, DeNardo DG. Zuo C, et al. J Exp Med. 2023 Jun 5;220(6):e20212062. doi: 10.1084/jem.20212062. Epub 2023 Mar 23. J Exp Med. 2023. PMID: 36951731 Free PMC article.