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Page 1
Pharmacogenomics of GPCR Drug Targets.
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM. Hauser AS, et al. Cell. 2018 Jan 11;172(1-2):41-54.e19. doi: 10.1016/j.cell.2017.11.033. Epub 2017 Dec 14. Cell. 2018. PMID: 29249361 Free PMC article.
Rules and mechanisms governing G protein coupling selectivity of GPCRs.
Masuho I, Kise R, Gainza P, Von Moo E, Li X, Tany R, Wakasugi-Masuho H, Correia BE, Martemyanov KA. Masuho I, et al. Cell Rep. 2023 Oct 31;42(10):113173. doi: 10.1016/j.celrep.2023.113173. Epub 2023 Sep 23. Cell Rep. 2023. PMID: 37742189 Free PMC article.
Severity of GNAO1-Related Disorder Correlates with Changes in G-Protein Function.
Domínguez-Carral J, Ludlam WG, Junyent Segarra M, Fornaguera Marti M, Balsells S, Muchart J, Čokolić Petrović D, Espinoza I, Ortigoza-Escobar JD, Martemyanov KA; GNAO1-Study Group. Domínguez-Carral J, et al. Ann Neurol. 2023 Nov;94(5):987-1004. doi: 10.1002/ana.26758. Epub 2023 Aug 31. Ann Neurol. 2023. PMID: 37548038 Free PMC article.
A Global Map of G Protein Signaling Regulation by RGS Proteins.
Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA. Masuho I, et al. Cell. 2020 Oct 15;183(2):503-521.e19. doi: 10.1016/j.cell.2020.08.052. Epub 2020 Oct 1. Cell. 2020. PMID: 33007266 Free PMC article.
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.
Members of the KCTD family are major regulators of cAMP signaling.
Muntean BS, Marwari S, Li X, Sloan DC, Young BD, Wohlschlegel JA, Martemyanov KA. Muntean BS, et al. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2119237119. doi: 10.1073/pnas.2119237119. Proc Natl Acad Sci U S A. 2022. PMID: 34934014 Free PMC article.
40 results