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Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
Kushnir A, Todd JJ, Witherspoon JW, Yuan Q, Reiken S, Lin H, Munce RH, Wajsberg B, Melville Z, Clarke OB, Wedderburn-Pugh K, Wronska A, Razaqyar MS, Chrismer IC, Shelton MO, Mankodi A, Grunseich C, Tarnopolsky MA, Tanji K, Hirano M, Riazi S, Kraeva N, Voermans NC, Gruber A, Allen C, Meilleur KG, Marks AR. Kushnir A, et al. Acta Neuropathol. 2020 Jun;139(6):1089-1104. doi: 10.1007/s00401-020-02150-w. Epub 2020 Mar 31. Acta Neuropathol. 2020. PMID: 32236737 Free PMC article.
Structural insights into the regulation of RyR1 by S100A1.
Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR. Weninger G, et al. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2400497121. doi: 10.1073/pnas.2400497121. Epub 2024 Jun 25. Proc Natl Acad Sci U S A. 2024. PMID: 38917010 Free PMC article.
IP3 receptor orchestrates maladaptive vascular responses in heart failure.
Dridi H, Santulli G, Gambardella J, Jankauskas SS, Yuan Q, Yang J, Reiken S, Wang X, Wronska A, Liu X, Lacampagne A, Marks AR. Dridi H, et al. J Clin Invest. 2022 Feb 15;132(4):e152859. doi: 10.1172/JCI152859. J Clin Invest. 2022. PMID: 35166236 Free PMC article.
Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity.
Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N. Zanou N, et al. Nat Commun. 2021 Dec 10;12(1):7219. doi: 10.1038/s41467-021-27422-1. Nat Commun. 2021. PMID: 34893614 Free PMC article.
17 results