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Page 1
Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.
Zhao S, Zhu Y, Schultz RD, Li N, He Z, Zhang Z, Caron A, Zhu Q, Sun K, Xiong W, Deng H, Sun J, Deng Y, Kim M, Lee CE, Gordillo R, Liu T, Odle AK, Childs GV, Zhang N, Kusminski CM, Elmquist JK, Williams KW, An Z, Scherer PE. Zhao S, et al. Cell Metab. 2019 Oct 1;30(4):706-719.e6. doi: 10.1016/j.cmet.2019.08.005. Epub 2019 Sep 5. Cell Metab. 2019. PMID: 31495688 Free PMC article.
Loss of transient receptor potential channel 5 causes obesity and postpartum depression.
Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Yang Y, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS. Li Y, et al. Cell. 2024 Aug 8;187(16):4176-4192.e17. doi: 10.1016/j.cell.2024.06.001. Epub 2024 Jul 2. Cell. 2024. PMID: 38959890 Free article.
GLP-1-directed NMDA receptor antagonism for obesity treatment.
Petersen J, Ludwig MQ, Juozaityte V, Ranea-Robles P, Svendsen C, Hwang E, Kristensen AW, Fadahunsi N, Lund J, Breum AW, Mathiesen CV, Sachs L, Moreno-Justicia R, Rohlfs R, Ford JC, Douros JD, Finan B, Portillo B, Grose K, Petersen JE, Trauelsen M, Feuchtinger A, DiMarchi RD, Schwartz TW, Deshmukh AS, Thomsen MB, Kohlmeier KA, Williams KW, Pers TH, Frølund B, Strømgaard K, Klein AB, Clemmensen C. Petersen J, et al. Nature. 2024 May;629(8014):1133-1141. doi: 10.1038/s41586-024-07419-8. Epub 2024 May 15. Nature. 2024. PMID: 38750368 Free PMC article.
GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans.
Kim KS, Park JS, Hwang E, Park MJ, Shin HY, Lee YH, Kim KM, Gautron L, Godschall E, Portillo B, Grose K, Jung SH, Baek SL, Yun YH, Lee D, Kim E, Ajwani J, Yoo SH, Güler AD, Williams KW, Choi HJ. Kim KS, et al. Science. 2024 Jul 26;385(6707):438-446. doi: 10.1126/science.adj2537. Epub 2024 Jun 27. Science. 2024. PMID: 38935778
Sustained inhibition of NPY/AgRP neuronal activity by FGF1.
Hwang E, Scarlett JM, Baquero AF, Bennett CM, Dong Y, Chau D, Brown JM, Mercer AJ, Meek TH, Grove KL, Phan BAN, Morton GJ, Williams KW, Schwartz MW. Hwang E, et al. JCI Insight. 2022 Sep 8;7(17):e160891. doi: 10.1172/jci.insight.160891. JCI Insight. 2022. PMID: 35917179 Free PMC article.
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