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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.
J Clin Invest. 2008.
PMID: 18382766
Free PMC article.
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.
Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB.
Dhillon H, et al.
Neuron. 2006 Jan 19;49(2):191-203. doi: 10.1016/j.neuron.2005.12.021.
Neuron. 2006.
PMID: 16423694
Free article.
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Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK.
Hill JW, et al.
Endocrinology. 2009 Nov;150(11):4874-82. doi: 10.1210/en.2009-0454. Epub 2009 Oct 9.
Endocrinology. 2009.
PMID: 19819947
Free PMC article.
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