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Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma.
Huang KC, Gomes C, Shiga Y, Belforte N, VanderWall KB, Lavekar SS, Fligor CM, Harkin J, Di Polo A, Meyer JS. Huang KC, et al. bioRxiv [Preprint]. 2023 Jan 4:2023.01.04.522687. doi: 10.1101/2023.01.04.522687. bioRxiv. 2023. Update in: Acta Neuropathol Commun. 2024 Oct 18;12(1):164. doi: 10.1186/s40478-024-01872-2 PMID: 36711831 Free PMC article. Updated. Preprint.
Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction.
Huang KC, Gomes C, Shiga Y, Belforte N, VanderWall KB, Lavekar SS, Fligor CM, Harkin J, Hetzer SM, Patil SV, Di Polo A, Meyer JS. Huang KC, et al. Acta Neuropathol Commun. 2024 Oct 18;12(1):164. doi: 10.1186/s40478-024-01872-2. Acta Neuropathol Commun. 2024. PMID: 39425218 Free PMC article.