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Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C, Zippin JH, van den Heuvel J, Glickman JF, Steegborn C, Levin LR, Buck J. Ramos-Espiritu L, et al. Nat Chem Biol. 2016 Oct;12(10):838-44. doi: 10.1038/nchembio.2151. Epub 2016 Aug 22. Nat Chem Biol. 2016. PMID: 27547922 Free PMC article.
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.
Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH. Ramos-Espiritu L, et al. Oncotarget. 2016 Jul 19;7(29):45597-45607. doi: 10.18632/oncotarget.10056. Oncotarget. 2016. PMID: 27323809 Free PMC article.