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Control of the embryonic stem cell state.
Young RA. Young RA. Cell. 2011 Mar 18;144(6):940-54. doi: 10.1016/j.cell.2011.01.032. Cell. 2011. PMID: 21414485 Free PMC article. Review.
BET bromodomain inhibition as a therapeutic strategy to target c-Myc.
Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, Bergsagel PL, Ghobrial IM, Richardson PG, Young RA, Hahn WC, Anderson KC, Kung AL, Bradner JE, Mitsiades CS. Delmore JE, et al. Cell. 2011 Sep 16;146(6):904-17. doi: 10.1016/j.cell.2011.08.017. Epub 2011 Sep 1. Cell. 2011. PMID: 21889194 Free PMC article.
Densely interconnected transcriptional circuits control cell states in human hematopoiesis.
Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. Novershtern N, et al. Cell. 2011 Jan 21;144(2):296-309. doi: 10.1016/j.cell.2011.01.004. Cell. 2011. PMID: 21241896 Free PMC article.
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.
Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI. Ceol CJ, et al. Nature. 2011 Mar 24;471(7339):513-7. doi: 10.1038/nature09806. Nature. 2011. PMID: 21430779 Free PMC article.
DHODH modulates transcriptional elongation in the neural crest and melanoma.
White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI. White RM, et al. Nature. 2011 Mar 24;471(7339):518-22. doi: 10.1038/nature09882. Nature. 2011. PMID: 21430780 Free PMC article.