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Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells.
Circ Res. 2009 Aug 28;105(5):471-80. doi: 10.1161/CIRCRESAHA.109.193656. Epub 2009 Jul 23.
Circ Res. 2009.
PMID: 19628794
Free PMC article.
mTOR is the rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr(389) in p70(S6k).
Hornberger TA, Sukhija KB, Wang XR, Chien S.
Hornberger TA, et al.
FEBS Lett. 2007 Oct 2;581(24):4562-6. doi: 10.1016/j.febslet.2007.08.045. Epub 2007 Aug 31.
FEBS Lett. 2007.
PMID: 17825298
Free PMC article.
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