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Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells.
Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y, Chien S, Chiu JJ. Tsai MC, et al. Circ Res. 2009 Aug 28;105(5):471-80. doi: 10.1161/CIRCRESAHA.109.193656. Epub 2009 Jul 23. Circ Res. 2009. PMID: 19628794 Free PMC article.