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The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity.
Tong Y, Lear TB, Evankovich J, Chen Y, Londino JD, Myerburg MM, Zhang Y, Popescu ID, McDyer JF, McVerry BJ, Lockwood KC, Jurczak MJ, Liu Y, Chen BB. Tong Y, et al. JCI Insight. 2020 Feb 13;5(3):e133652. doi: 10.1172/jci.insight.133652. JCI Insight. 2020. PMID: 31990690 Free PMC article.
KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Lear TB, McKelvey AC, Evankovich JW, Rajbhandari S, Coon TA, Dunn SR, Londino JD, McVerry BJ, Zhang Y, Valenzi E, Burton CL, Gordon R, Gingras S, Lockwood KC, Jurczak MJ, Lafyatis R, Shlomchik MJ, Liu Y, Chen BB. Lear TB, et al. JCI Insight. 2019 Oct 3;4(19):e129110. doi: 10.1172/jci.insight.129110. JCI Insight. 2019. PMID: 31578312 Free PMC article.
Modulation of lysosomal function as a therapeutic approach for coronaviral infections.
Liu Y, Lear T, Larsen M, Lin B, Cao Q, Alfaras I, Kennerdell J, Salminen L, Camarco D, Lockwood K, Ma J, Liu J, Tan J, Myerburg M, Chen Y, St Croix C, Sekine Y, Evankovich J, Finkel T, Chen B. Liu Y, et al. Res Sq [Preprint]. 2021 Apr 23:rs.3.rs-419305. doi: 10.21203/rs.3.rs-419305/v1. Res Sq. 2021. PMID: 34013250 Free PMC article. Preprint.
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O'Donnell CP, Finkel T, Chen BB, Mallampalli RK. Liu Y, et al. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. Nat Chem Biol. 2021. PMID: 33495648 Free PMC article.
14 results