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Page 1
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.
Kadur Lakshminarasimha Murthy P, Sontake V, Tata A, Kobayashi Y, Macadlo L, Okuda K, Conchola AS, Nakano S, Gregory S, Miller LA, Spence JR, Engelhardt JF, Boucher RC, Rock JR, Randell SH, Tata PR. Kadur Lakshminarasimha Murthy P, et al. Nature. 2022 Apr;604(7904):111-119. doi: 10.1038/s41586-022-04541-3. Epub 2022 Mar 30. Nature. 2022. PMID: 35355018 Free PMC article.
Human distal airways contain a multipotent secretory cell that can regenerate alveoli.
Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Basil MC, et al. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355013 Free PMC article.
Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis.
Wang S, Rao W, Hoffman A, Lin J, Li J, Lin T, Liew AA, Vincent M, Mertens TCJ, Karmouty-Quintana H, Crum CP, Metersky ML, Schwartz DA, Davies PJA, Stephan C, Jyothula SSK, Sheshadri A, Suarez EE, Huang HJ, Engelhardt JF, Dickey BF, Parekh KR, McKeon FD, Xian W. Wang S, et al. Sci Transl Med. 2023 Apr 26;15(693):eabp9528. doi: 10.1126/scitranslmed.abp9528. Epub 2023 Apr 26. Sci Transl Med. 2023. PMID: 37099633 Free PMC article.
Transgenic ferret models define pulmonary ionocyte diversity and function.
Yuan F, Gasser GN, Lemire E, Montoro DT, Jagadeesh K, Zhang Y, Duan Y, Ievlev V, Wells KL, Rotti PG, Shahin W, Winter M, Rosen BH, Evans I, Cai Q, Yu M, Walsh SA, Acevedo MR, Pandya DN, Akurathi V, Dick DW, Wadas TJ, Joo NS, Wine JJ, Birket S, Fernandez CM, Leung HM, Tearney GJ, Verkman AS, Haggie PM, Scott K, Bartels D, Meyerholz DK, Rowe SM, Liu X, Yan Z, Haber AL, Sun X, Engelhardt JF. Yuan F, et al. Nature. 2023 Sep;621(7980):857-867. doi: 10.1038/s41586-023-06549-9. Epub 2023 Sep 20. Nature. 2023. PMID: 37730992 Free PMC article.
In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets.
Evans IA, Sun X, Liang B, Vegter AR, Guo L, Lynch TJ, Zhang Y, Zhang Y, Yi Y, Yang Y, Feng Z, Park SY, Shonka A, McCumber H, Qi L, Wu P, Liu G, Lacina A, Wang K, Gibson-Corley KN, Meyerholz DK, Limoli DH, Rosen BH, Yan Z, Bartels DJ, Engelhardt JF. Evans IA, et al. JCI Insight. 2024 Apr 22;9(8):e157229. doi: 10.1172/jci.insight.157229. JCI Insight. 2024. PMID: 38646935 Free PMC article.
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