R01 MH082867/MH/NIMH NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2008	3
2009	6
2010	7
2011	4
2012	9
2013	6
2014	3
2015	4
2016	6
2017	5
2018	8
2019	2
2021	1
2024	1

1

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Lindsley CW, Emmitte KA, Hopkins CR, Bridges TM, Gregory KJ, Niswender CM, Conn PJ. Lindsley CW, et al. Chem Rev. 2016 Jun 8;116(11):6707-41. doi: 10.1021/acs.chemrev.5b00656. Epub 2016 Feb 16. Chem Rev. 2016. PMID: 26882314 Free PMC article. Review.

2

2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites.

Lindsley CW. Lindsley CW. J Med Chem. 2014 Sep 25;57(18):7485-98. doi: 10.1021/jm5011786. Epub 2014 Sep 15. J Med Chem. 2014. PMID: 25180768 Free PMC article. Review.

3

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease.

Melancon BJ, Tarr JC, Panarese JD, Wood MR, Lindsley CW. Melancon BJ, et al. Drug Discov Today. 2013 Dec;18(23-24):1185-99. doi: 10.1016/j.drudis.2013.09.005. Epub 2013 Sep 17. Drug Discov Today. 2013. PMID: 24051397 Free PMC article. Review.

4

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.

Conn PJ, Jones CK, Lindsley CW. Conn PJ, et al. Trends Pharmacol Sci. 2009 Mar;30(3):148-55. doi: 10.1016/j.tips.2008.12.002. Epub 2009 Feb 7. Trends Pharmacol Sci. 2009. PMID: 19201489 Free PMC article. Review.

5

Discovery of VU6007496: Challenges in the Development of an M₁ Positive Allosteric Modulator Backup Candidate.

Engers JL, Bollinger KA, Capstick RA, Long MF, Bender AM, Dickerson JW, Peng W, Presley CC, Cho HP, Rodriguez AL, Niswender CM, Moran SP, Xiang Z, Blobaum AL, Boutaud O, Rook JM, Engers DW, Conn PJ, Lindsley CW. Engers JL, et al. ACS Chem Neurosci. 2024 Sep 18;15(18):3421-3433. doi: 10.1021/acschemneuro.4c00508. Epub 2024 Aug 28. ACS Chem Neurosci. 2024. PMID: 39197083 Free PMC article.

6

Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.

Conn PJ, Lindsley CW, Meiler J, Niswender CM. Conn PJ, et al. Nat Rev Drug Discov. 2014 Sep;13(9):692-708. doi: 10.1038/nrd4308. Nat Rev Drug Discov. 2014. PMID: 25176435 Free PMC article. Review.

7

Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders.

Engers DW, Lindsley CW. Engers DW, et al. Drug Discov Today Technol. 2013 Summer;10(2):e269-76. doi: 10.1016/j.ddtec.2012.10.007. Drug Discov Today Technol. 2013. PMID: 24050278 Free PMC article. Review.

8

Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M₁ Positive Allosteric Modulators.

Engers JL, Bender AM, Kalbfleisch JJ, Cho HP, Lingenfelter KS, Luscombe VB, Han C, Melancon BJ, Blobaum AL, Dickerson JW, Rook JM, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW. Engers JL, et al. ACS Chem Neurosci. 2019 Mar 20;10(3):1035-1042. doi: 10.1021/acschemneuro.8b00311. Epub 2018 Aug 9. ACS Chem Neurosci. 2019. PMID: 30086237 Free PMC article.

9

Structure-Activity Relationships of Pan-Gα_q/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators.

Berizzi AE, Bender AM, Lindsley CW, Conn PJ, Sexton PM, Langmead CJ, Christopoulos A. Berizzi AE, et al. ACS Chem Neurosci. 2018 Jul 18;9(7):1818-1828. doi: 10.1021/acschemneuro.8b00136. Epub 2018 Apr 30. ACS Chem Neurosci. 2018. PMID: 29683647 Free PMC article.

10

Discovery and Optimization of Potent and CNS Penetrant M₅-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.

Bender AM, Cho HP, Nance KD, Lingenfelter KS, Luscombe VB, Gentry PR, Voigtritter K, Berizzi AE, Sexton PM, Langmead CJ, Christopoulos A, Locuson CW, Bridges TM, Chang S, O'Neill JC, Zhan X, Niswender CM, Jones CK, Conn PJ, Lindsley CW. Bender AM, et al. ACS Chem Neurosci. 2018 Jul 18;9(7):1572-1581. doi: 10.1021/acschemneuro.8b00126. Epub 2018 Apr 26. ACS Chem Neurosci. 2018. PMID: 29678111 Free PMC article.

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