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Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Aguilar R, Spencer KB, Kesner B, Rizvi NF, Badmalia MD, Mrozowich T, Mortison JD, Rivera C, Smith GF, Burchard J, Dandliker PJ, Patel TR, Nickbarg EB, Lee JT. Aguilar R, et al. Nature. 2022 Apr;604(7904):160-166. doi: 10.1038/s41586-022-04537-z. Epub 2022 Mar 30. Nature. 2022. PMID: 35355011 Free PMC article.
Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.
Generoso SF, Neguembor MV, Hershberg EA, Sadreyev RI, Kurimoto K, Yabuta Y, Ricci R, Audergon P, Bauer M, Saitou M, Hochedlinger K, Beliveau BJ, Cosma MP, Lee JT, Payer B. Generoso SF, et al. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2213810120. doi: 10.1073/pnas.2213810120. Epub 2023 Jan 20. Proc Natl Acad Sci U S A. 2023. PMID: 36669113 Free PMC article.