R01 NS041777/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2004	1
2005	3
2006	1
2007	6
2008	11
2009	8
2010	2
2011	3
2012	3
2013	1
2022	1
2023	1
2024	3

1

Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.

Shoop WK, Lape J, Trum M, Powell A, Sevigny E, Mischler A, Bacman SR, Fontanesi F, Smith J, Jantz D, Gorsuch CL, Moraes CT. Shoop WK, et al. Nat Metab. 2023 Dec;5(12):2169-2183. doi: 10.1038/s42255-023-00932-6. Epub 2023 Nov 30. Nat Metab. 2023. PMID: 38036771 Free PMC article.

2

Mitochondrial biogenesis and turnover.

Diaz F, Moraes CT. Diaz F, et al. Cell Calcium. 2008 Jul;44(1):24-35. doi: 10.1016/j.ceca.2007.12.004. Epub 2008 Apr 18. Cell Calcium. 2008. PMID: 18395251 Free PMC article. Review.

3

Linear DNA-driven recombination in mammalian mitochondria.

Fragkoulis G, Hangas A, Fekete Z, Michell C, Moraes CT, Willcox S, Griffith JD, Goffart S, Pohjoismäki JLO. Fragkoulis G, et al. Nucleic Acids Res. 2024 Apr 12;52(6):3088-3105. doi: 10.1093/nar/gkae040. Nucleic Acids Res. 2024. PMID: 38300793 Free PMC article.

4

Mitochondrial transcription: lessons from mouse models.

Peralta S, Wang X, Moraes CT. Peralta S, et al. Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):961-9. doi: 10.1016/j.bbagrm.2011.11.001. Epub 2011 Nov 18. Biochim Biophys Acta. 2012. PMID: 22120174 Free PMC article. Review.

5

Precise and simultaneous quantification of mitochondrial DNA heteroplasmy and copy number by digital PCR.

Shoop WK, Gorsuch CL, Bacman SR, Moraes CT. Shoop WK, et al. J Biol Chem. 2022 Nov;298(11):102574. doi: 10.1016/j.jbc.2022.102574. Epub 2022 Oct 6. J Biol Chem. 2022. PMID: 36209825 Free PMC article.

6

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

Fukui H, Moraes CT. Fukui H, et al. Trends Neurosci. 2008 May;31(5):251-6. doi: 10.1016/j.tins.2008.02.008. Epub 2008 Apr 9. Trends Neurosci. 2008. PMID: 18403030 Free PMC article. Review.

7

Mouse models of Parkinson's disease associated with mitochondrial dysfunction.

Pickrell AM, Pinto M, Moraes CT. Pickrell AM, et al. Mol Cell Neurosci. 2013 Jul;55:87-94. doi: 10.1016/j.mcn.2012.08.002. Epub 2012 Aug 11. Mol Cell Neurosci. 2013. PMID: 22954895 Free PMC article. Review.

8

mitoTALEN reduces the mutant mtDNA load in neurons.

Bacman SR, Barrera-Paez JD, Pinto M, Van Booven D, Stewart JB, Griswold AJ, Moraes CT. Bacman SR, et al. Mol Ther Nucleic Acids. 2024 Feb 2;35(1):102132. doi: 10.1016/j.omtn.2024.102132. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38404505 Free PMC article.

9

Mitochondrial disorders caused by mutations in respiratory chain assembly factors.

Diaz F, Kotarsky H, Fellman V, Moraes CT. Diaz F, et al. Semin Fetal Neonatal Med. 2011 Aug;16(4):197-204. doi: 10.1016/j.siny.2011.05.004. Epub 2011 Jun 15. Semin Fetal Neonatal Med. 2011. PMID: 21680271 Free PMC article. Review.

10

Absence of both MGME1 and POLG EXO abolishes mtDNA whereas absence of either creates unique mtDNA duplications.

Gonzalez CD, Nissanka N, Van Booven D, Griswold AJ, Moraes CT. Gonzalez CD, et al. J Biol Chem. 2024 Apr;300(4):107128. doi: 10.1016/j.jbc.2024.107128. Epub 2024 Mar 1. J Biol Chem. 2024. PMID: 38432635 Free PMC article.

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