R01 NS121114/NS/NINDS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2021	4
2022	8
2023	13
2024	11

1

A conceptual framework for understanding phase separation and addressing open questions and challenges.

Mittag T, Pappu RV. Mittag T, et al. Mol Cell. 2022 Jun 16;82(12):2201-2214. doi: 10.1016/j.molcel.2022.05.018. Epub 2022 Jun 7. Mol Cell. 2022. PMID: 35675815 Free PMC article. Review.

2

Emergent microenvironments of nucleoli.

King MR, Ruff KM, Pappu RV. King MR, et al. Nucleus. 2024 Dec;15(1):2319957. doi: 10.1080/19491034.2024.2319957. Epub 2024 Mar 5. Nucleus. 2024. PMID: 38443761 Free PMC article. Review.

3

Phase Transitions of Associative Biomacromolecules.

Pappu RV, Cohen SR, Dar F, Farag M, Kar M. Pappu RV, et al. Chem Rev. 2023 Jul 26;123(14):8945-8987. doi: 10.1021/acs.chemrev.2c00814. Epub 2023 Mar 7. Chem Rev. 2023. PMID: 36881934 Free PMC article. Review.

4

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions.

Farag M, Borcherds WM, Bremer A, Mittag T, Pappu RV. Farag M, et al. Nat Commun. 2023 Sep 8;14(1):5527. doi: 10.1038/s41467-023-41274-x. Nat Commun. 2023. PMID: 37684240 Free PMC article.

5

Dynamical control enables the formation of demixed biomolecular condensates.

Lin AZ, Ruff KM, Dar F, Jalihal A, King MR, Lalmansingh JM, Posey AE, Erkamp NA, Seim I, Gladfelter AS, Pappu RV. Lin AZ, et al. Nat Commun. 2023 Nov 24;14(1):7678. doi: 10.1038/s41467-023-43489-4. Nat Commun. 2023. PMID: 37996438 Free PMC article.

6

Fusion proteins form onco-condensates.

Mittag T, Ansari AZ. Mittag T, et al. Nat Struct Mol Biol. 2021 Jul;28(7):543-545. doi: 10.1038/s41594-021-00608-3. Nat Struct Mol Biol. 2021. PMID: 34163089 No abstract available.

7

Developments in describing equilibrium phase transitions of multivalent associative macromolecules.

Zeng X, Pappu RV. Zeng X, et al. Curr Opin Struct Biol. 2023 Apr;79:102540. doi: 10.1016/j.sbi.2023.102540. Epub 2023 Feb 16. Curr Opin Struct Biol. 2023. PMID: 36804705 Free PMC article. Review.

8

Metastable condensates suppress conversion to amyloid fibrils.

Das T, Zaidi F, Farag M, Ruff KM, Messing J, Taylor JP, Pappu RV, Mittag T. Das T, et al. bioRxiv [Preprint]. 2024 Mar 3:2024.02.28.582569. doi: 10.1101/2024.02.28.582569. bioRxiv. 2024. PMID: 38464104 Free PMC article. Preprint.

9

Solutes unmask differences in clustering versus phase separation of FET proteins.

Kar M, Vogel LT, Chauhan G, Felekyan S, Ausserwöger H, Welsh TJ, Dar F, Kamath AR, Knowles TPJ, Hyman AA, Seidel CAM, Pappu RV. Kar M, et al. Nat Commun. 2024 May 23;15(1):4408. doi: 10.1038/s41467-024-48775-3. Nat Commun. 2024. PMID: 38782886 Free PMC article.

10

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.

Kar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CAM, Knowles TPJ, Hyman AA, Pappu RV. Kar M, et al. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2202222119. doi: 10.1073/pnas.2202222119. Epub 2022 Jul 5. Proc Natl Acad Sci U S A. 2022. PMID: 35787038 Free PMC article.

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