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Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
J Biol Chem. 2009 Jan 30;284(5):2967-2977. doi: 10.1074/jbc.M807269200. Epub 2008 Nov 25.
J Biol Chem. 2009.
PMID: 19036728
Free PMC article.
Modulation of gamma-secretase specificity using small molecule allosteric inhibitors.
Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM.
Shelton CC, et al.
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20228-33. doi: 10.1073/pnas.0910757106. Epub 2009 Nov 11.
Proc Natl Acad Sci U S A. 2009.
PMID: 19906985
Free PMC article.
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Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.
Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT.
Hernandez CM, et al.
J Neurosci. 2010 Feb 17;30(7):2442-53. doi: 10.1523/JNEUROSCI.5038-09.2010.
J Neurosci. 2010.
PMID: 20164328
Free PMC article.
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