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A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. Wei K, et al. Nat Med. 2013 Oct;19(10):1331-1337. doi: 10.1038/nm.3295. Epub 2013 Sep 15. Nat Med. 2013. PMID: 24037094 Free PMC article.