R21 AI094715/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2011	5
2012	8
2013	4
2014	1
2015	1
2025	0

1

Antiviral therapies: focus on hepatitis B reverse transcriptase.

Michailidis E, Kirby KA, Hachiya A, Yoo W, Hong SP, Kim SO, Folk WR, Sarafianos SG. Michailidis E, et al. Int J Biochem Cell Biol. 2012 Jul;44(7):1060-71. doi: 10.1016/j.biocel.2012.04.006. Epub 2012 Apr 16. Int J Biochem Cell Biol. 2012. PMID: 22531713 Free PMC article. Review.

2

Mechanism of nucleic acid unwinding by SARS-CoV helicase.

Adedeji AO, Marchand B, Te Velthuis AJ, Snijder EJ, Weiss S, Eoff RL, Singh K, Sarafianos SG. Adedeji AO, et al. PLoS One. 2012;7(5):e36521. doi: 10.1371/journal.pone.0036521. Epub 2012 May 15. PLoS One. 2012. PMID: 22615777 Free PMC article.

3

Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms.

Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Adedeji AO, et al. J Virol. 2013 Jul;87(14):8017-28. doi: 10.1128/JVI.00998-13. Epub 2013 May 15. J Virol. 2013. PMID: 23678171 Free PMC article.

4

Evaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs.

Hachiya A, Reeve AB, Marchand B, Michailidis E, Ong YT, Kirby KA, Leslie MD, Oka S, Kodama EN, Rohan LC, Mitsuya H, Parniak MA, Sarafianos SG. Hachiya A, et al. Antimicrob Agents Chemother. 2013 Sep;57(9):4554-4558. doi: 10.1128/AAC.00283-13. Epub 2013 Jun 24. Antimicrob Agents Chemother. 2013. PMID: 23796932 Free PMC article.

5

Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effects on T-20.

Izumi K, Watanabe K, Oishi S, Fujii N, Matsuoka M, Sarafianos SG, Kodama EN. Izumi K, et al. Antivir Chem Chemother. 2011 Aug 23;22(1):51-5. doi: 10.3851/IMP1836. Antivir Chem Chemother. 2011. PMID: 21860071 Free PMC article.

6

K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.

Hachiya A, Kodama EN, Schuckmann MM, Kirby KA, Michailidis E, Sakagami Y, Oka S, Singh K, Sarafianos SG. Hachiya A, et al. PLoS One. 2011 Jan 13;6(1):e16242. doi: 10.1371/journal.pone.0016242. PLoS One. 2011. PMID: 21249155 Free PMC article.

7

Preparation of biologically active single-chain variable antibody fragments that target the HIV-1 gp120 V3 loop.

Ong YT, Kirby KA, Hachiya A, Chiang LA, Marchand B, Yoshimura K, Murakami T, Singh K, Matsushita S, Sarafianos SG. Ong YT, et al. Cell Mol Biol (Noisy-le-grand). 2012 Dec 22;58(1):71-9. Cell Mol Biol (Noisy-le-grand). 2012. PMID: 23273194 Free PMC article.

8

Structural and biochemical basis for the difference in the helicase activity of two different constructs of SARS-CoV helicase.

Adedeji AO, Singh K, Sarafianos SG. Adedeji AO, et al. Cell Mol Biol (Noisy-le-grand). 2012 Dec 22;58(1):114-21. Cell Mol Biol (Noisy-le-grand). 2012. PMID: 23273200 Free PMC article.

9

Structural basis of clade-specific HIV-1 neutralization by humanized anti-V3 monoclonal antibody KD-247.

Kirby KA, Ong YT, Hachiya A, Laughlin TG, Chiang LA, Pan Y, Moran JL, Marchand B, Singh K, Gallazzi F, Quinn TP, Yoshimura K, Murakami T, Matsushita S, Sarafianos SG. Kirby KA, et al. FASEB J. 2015 Jan;29(1):70-80. doi: 10.1096/fj.14-252262. Epub 2014 Oct 28. FASEB J. 2015. PMID: 25351987 Free PMC article.

10

Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.

Sohl CD, Singh K, Kasiviswanathan R, Copeland WC, Mitsuya H, Sarafianos SG, Anderson KS. Sohl CD, et al. Antimicrob Agents Chemother. 2012 Mar;56(3):1630-4. doi: 10.1128/AAC.05729-11. Epub 2011 Dec 12. Antimicrob Agents Chemother. 2012. PMID: 22155823 Free PMC article.

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