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Cycloserine did not increase depression incidence or severity at standard dosing for multidrug-resistant tuberculosis.
Tornheim JA, Udwadia ZF, Arora PR, Gajjar I, Gupte N, Sharma S, Karane M, Sawant N, Kharat N, Blum AJ, Shivakumar SVBY, Mullerpattan JB, Pinto LM, Ashavaid TF, Gupta A, Rodrigues C. Tornheim JA, et al. Eur Respir J. 2022 Mar 24;59(3):2102511. doi: 10.1183/13993003.02511-2021. Print 2022 Mar. Eur Respir J. 2022. PMID: 34949698 Free PMC article.
Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence.
Dutta NK, Klinkenberg LG, Vazquez MJ, Segura-Carro D, Colmenarejo G, Ramon F, Rodriguez-Miquel B, Mata-Cantero L, Porras-De Francisco E, Chuang YM, Rubin H, Lee JJ, Eoh H, Bader JS, Perez-Herran E, Mendoza-Losana A, Karakousis PC. Dutta NK, et al. Sci Adv. 2019 Mar 20;5(3):eaav2104. doi: 10.1126/sciadv.aav2104. eCollection 2019 Mar. Sci Adv. 2019. PMID: 30906866 Free PMC article.
Transcriptomic Profiles of Confirmed Pediatric Tuberculosis Patients and Household Contacts Identifies Active Tuberculosis, Infection, and Treatment Response Among Indian Children.
Tornheim JA, Madugundu AK, Paradkar M, Fukutani KF, Queiroz ATL, Gupte N, Gupte AN, Kinikar A, Kulkarni V, Balasubramanian U, Sreenivasamurthy S, Raja R, Pradhan N, Shivakumar SVBY, Valvi C, Hanna LE, Andrade BB, Mave V, Pandey A, Gupta A; CTRIUMPh RePORT India Study Team. Tornheim JA, et al. J Infect Dis. 2020 Apr 27;221(10):1647-1658. doi: 10.1093/infdis/jiz639. J Infect Dis. 2020. PMID: 31796955 Free PMC article.
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