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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Membrez M, et al. Nat Metab. 2024 Mar;6(3):433-447. doi: 10.1038/s42255-024-00997-x. Epub 2024 Mar 19. Nat Metab. 2024. PMID: 38504132 Free PMC article.
The chemistry of the vitamin B3 metabolome.
Makarov MV, Trammell SAJ, Migaud ME. Makarov MV, et al. Biochem Soc Trans. 2019 Feb 28;47(1):131-147. doi: 10.1042/BST20180420. Epub 2018 Dec 17. Biochem Soc Trans. 2019. PMID: 30559273 Free PMC article. Review.
Scalable syntheses of traceable ribosylated NAD+ precursors.
Makarov MV, Harris NW, Rodrigues M, Migaud ME. Makarov MV, et al. Org Biomol Chem. 2019 Oct 14;17(38):8716-8720. doi: 10.1039/c9ob01981b. Epub 2019 Sep 20. Org Biomol Chem. 2019. PMID: 31538639 Free PMC article.
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