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Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma.
Sroka MW, Skopelitis D, Vermunt MW, Preall JB, El Demerdash O, de Almeida LMN, Chang K, Utama R, Gryder B, Caligiuri G, Ren D, Nalbant B, Milazzo JP, Tuveson DA, Dobin A, Hiebert SW, Stengel KR, Mantovani R, Khan J, Kohli RM, Shi J, Blobel GA, Vakoc CR. Sroka MW, et al. Proc Natl Acad Sci U S A. 2023 Sep 5;120(36):e2303859120. doi: 10.1073/pnas.2303859120. Epub 2023 Aug 28. Proc Natl Acad Sci U S A. 2023. PMID: 37639593 Free PMC article.
MARK2/MARK3 Kinases Are Catalytic Codependencies of YAP/TAZ in Human Cancer.
Klingbeil O, Skopelitis D, Tonelli C, Yoshimoto T, Alpsoy A, Panepinto MC, Minicozzi F, Merrill JR, Cafiero AM, Aggarwal D, Russo S, Ha T, Demerdash OE, Wee TL, Spector DL, Lyons SK, Tuveson DA, Cifani P, Vakoc CR. Klingbeil O, et al. Cancer Discov. 2024 Dec 2;14(12):2471-2488. doi: 10.1158/2159-8290.CD-23-1529. Cancer Discov. 2024. PMID: 39058094 Free PMC article.
SMARCA4 biology in alveolar rhabdomyosarcoma.
Bharathy N, Cleary MM, Kim JA, Nagamori K, Crawford KA, Wang E, Saha D, Settelmeyer TP, Purohit R, Skopelitis D, Chang K, Doran JA, Kirschbaum CW, Bharathy S, Crews DW, Randolph ME, Karnezis AN, Hudson-Price L, Dhawan J, Michalek JE, Ciulli A, Vakoc CR, Keller C. Bharathy N, et al. Oncogene. 2022 Mar;41(11):1647-1656. doi: 10.1038/s41388-022-02205-0. Epub 2022 Jan 29. Oncogene. 2022. PMID: 35094009 Free PMC article.
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma.
Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Gryder BE, et al. Nat Genet. 2019 Dec;51(12):1714-1722. doi: 10.1038/s41588-019-0534-4. Epub 2019 Nov 29. Nat Genet. 2019. PMID: 31784732 Free PMC article.
Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage.
Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Gryder BE, et al. iScience. 2020 May 22;23(5):101103. doi: 10.1016/j.isci.2020.101103. Epub 2020 Apr 29. iScience. 2020. PMID: 32416589 Free PMC article.