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Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer.
Miller KD, O'Connor S, Pniewski KA, Kannan T, Acosta R, Mirji G, Papp S, Hulse M, Mukha D, Hlavaty SI, Salcido KN, Bertolazzi F, Srikanth YVV, Zhao S, Wellen KE, Shinde RS, Claiborne DT, Kossenkov A, Salvino JM, Schug ZT. Miller KD, et al. Nat Cancer. 2023 Oct;4(10):1491-1507. doi: 10.1038/s43018-023-00636-6. Epub 2023 Sep 18. Nat Cancer. 2023. PMID: 37723305 Free PMC article.
Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer.
Murphy B, Miyamoto T, Manning BS, Mirji G, Ugolini A, Kannan T, Hamada K, Zhu YP, Claiborne DT, Huang L, Zhang R, Nefedova Y, Kossenkov A, Veglia F, Shinde R, Zhang N. Murphy B, et al. bioRxiv [Preprint]. 2024 Jun 29:2024.06.25.600597. doi: 10.1101/2024.06.25.600597. bioRxiv. 2024. Update in: J Exp Med. 2024 Dec 2;221(12):e20231967. doi: 10.1084/jem.20231967 PMID: 38979222 Free PMC article. Updated. Preprint.
Alterations in bone metabolites with age in C57BL/6 mice model.
Patel D, Lee TJ, Kumar S, Vyavahare S, Worth A, Hill WD, Hamrick M, Isales CM, Shinde RS, Fulzele S. Patel D, et al. Biogerontology. 2022 Oct;23(5):629-640. doi: 10.1007/s10522-022-09986-7. Epub 2022 Sep 2. Biogerontology. 2022. PMID: 36056226 Free PMC article.