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The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Sabio Ortiz J, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyö D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG. Ravn-Boess N, et al. Cell Rep. 2023 Nov 28;42(11):113374. doi: 10.1016/j.celrep.2023.113374. Epub 2023 Nov 8. Cell Rep. 2023. PMID: 37938973 Free PMC article.
PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.
Frenster JD, Erdjument-Bromage H, Stephan G, Ravn-Boess N, Wang S, Liu W, Bready D, Wilcox J, Kieslich B, Jankovic M, Wilde C, Horn S, Sträter N, Liebscher I, Schöneberg T, Fenyo D, Neubert TA, Placantonakis DG. Frenster JD, et al. Cell Rep. 2023 Jul 25;42(7):112679. doi: 10.1016/j.celrep.2023.112679. Epub 2023 Jun 23. Cell Rep. 2023. PMID: 37354459 Free PMC article.
Modulation of GPR133 (ADGRD1) Signaling by its Intracellular Interaction Partner Extended Synaptotagmin 1 (ESYT1).
Stephan G, Erdjument-Bromage H, Liu W, Frenster JD, Ravn-Boess N, Bready D, Cai J, Fenyo D, Neubert T, Placantonakis DG. Stephan G, et al. bioRxiv [Preprint]. 2023 Feb 9:2023.02.09.527921. doi: 10.1101/2023.02.09.527921. bioRxiv. 2023. Update in: Cell Rep. 2024 May 28;43(5):114229. doi: 10.1016/j.celrep.2024.114229 PMID: 36798364 Free PMC article. Updated. Preprint.