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The TLQP-21 peptide activates the G-protein-coupled receptor C3aR1 via a folding-upon-binding mechanism.
Structure. 2014 Dec 2;22(12):1744-1753. doi: 10.1016/j.str.2014.10.001. Epub 2014 Nov 13.
Structure. 2014.
PMID: 25456411
Free PMC article.
The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity.
Fairbanks CA, Peterson CD, Speltz RH, Riedl MS, Kitto KF, Dykstra JA, Braun PD, Sadahiro M, Salton SR, Vulchanova L.
Fairbanks CA, et al.
Pain. 2014 Jul;155(7):1229-1237. doi: 10.1016/j.pain.2014.03.012. Epub 2014 Mar 21.
Pain. 2014.
PMID: 24657450
Free PMC article.
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