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Page 1
Hepcidin and Hfe in iron overload in beta-thalassemia.
Gardenghi S, Ramos P, Follenzi A, Rao N, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Ann N Y Acad Sci. 2010 Aug;1202:221-5. doi: 10.1111/j.1749-6632.2010.05595.x. Ann N Y Acad Sci. 2010. PMID: 20712796 Free PMC article. Review.
Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.
Breveglieri G, Mancini I, Bianchi N, Lampronti I, Salvatori F, Fabbri E, Zuccato C, Cosenza LC, Montagner G, Borgatti M, Altruda F, Fagoonee S, Carandina G, Rubini M, Aiello V, Breda L, Rivella S, Gambari R, Finotti A. Breveglieri G, et al. Biomed Res Int. 2015;2015:687635. doi: 10.1155/2015/687635. Epub 2015 May 4. Biomed Res Int. 2015. PMID: 26097845 Free PMC article.
Ineffective erythropoiesis and thalassemias.
Rivella S. Rivella S. Curr Opin Hematol. 2009 May;16(3):187-94. doi: 10.1097/MOH.0b013e32832990a4. Curr Opin Hematol. 2009. PMID: 19318943 Free PMC article. Review.
Future alternative therapies for β-thalassemia.
Rivella S, Rachmilewitz E. Rivella S, et al. Expert Rev Hematol. 2009 Dec 1;2(6):685. doi: 10.1586/ehm.09.56. Expert Rev Hematol. 2009. PMID: 20174612 Free PMC article.
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.
Libani IV, Guy EC, Melchiori L, Schiro R, Ramos P, Breda L, Scholzen T, Chadburn A, Liu Y, Kernbach M, Baron-Lühr B, Porotto M, de Sousa M, Rachmilewitz EA, Hood JD, Cappellini MD, Giardina PJ, Grady RW, Gerdes J, Rivella S. Libani IV, et al. Blood. 2008 Aug 1;112(3):875-85. doi: 10.1182/blood-2007-12-126938. Epub 2008 May 14. Blood. 2008. PMID: 18480424 Free PMC article.
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, Chadburn A, Liu Y, Amariglio N, Rechavi G, Rachmilewitz EA, Breuer W, Cabantchik ZI, Wrighting DM, Andrews NC, de Sousa M, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Blood. 2007 Jun 1;109(11):5027-35. doi: 10.1182/blood-2006-09-048868. Epub 2007 Feb 13. Blood. 2007. PMID: 17299088 Free PMC article.