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Page 1
A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.
Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE. Sheu SH, et al. Cell. 2022 Sep 1;185(18):3390-3407.e18. doi: 10.1016/j.cell.2022.07.026. Cell. 2022. PMID: 36055200 Free PMC article.
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. Magupalli VG, et al. Science. 2020 Sep 18;369(6510):eaas8995. doi: 10.1126/science.aas8995. Science. 2020. PMID: 32943500 Free PMC article.
Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface.
Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK. Shipley FB, et al. Neuron. 2020 Nov 25;108(4):623-639.e10. doi: 10.1016/j.neuron.2020.08.024. Epub 2020 Sep 21. Neuron. 2020. PMID: 32961128 Free PMC article.
SARS-CoV-2 requires acidic pH to infect cells.
Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Correia RBDC, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T. Kreutzberger AJB, et al. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2209514119. doi: 10.1073/pnas.2209514119. Epub 2022 Sep 1. Proc Natl Acad Sci U S A. 2022. PMID: 36048924 Free PMC article.
Constitutive Endolysosomal Perforation in Neurons allows Induction of α-Synuclein Aggregation by Internalized Pre-Formed Fibrils.
Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Oikonomou A, Hatzakis NS, Kirchhausen T. Sanyal A, et al. bioRxiv [Preprint]. 2024 Jan 1:2023.12.30.573738. doi: 10.1101/2023.12.30.573738. bioRxiv. 2024. Update in: J Cell Biol. 2025 Feb 3;224(2):e202401136. doi: 10.1083/jcb.202401136 PMID: 38260258 Free PMC article. Updated. Preprint.
A spatiotemporal Notch interaction map from plasma membrane to nucleus.
Martin AP, Bradshaw GA, Eisert RJ, Egan ED, Tveriakhina L, Rogers JM, Dates AN, Scanavachi G, Aster JC, Kirchhausen T, Kalocsay M, Blacklow SC. Martin AP, et al. Sci Signal. 2023 Aug;16(796):eadg6474. doi: 10.1126/scisignal.adg6474. Epub 2023 Aug 1. Sci Signal. 2023. PMID: 37527352 Free PMC article.
SARS-CoV-2 requires acidic pH to infect cells.
Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Bango Da Cunha Correira R, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T. Kreutzberger AJB, et al. bioRxiv [Preprint]. 2022 Jun 14:2022.06.09.495472. doi: 10.1101/2022.06.09.495472. bioRxiv. 2022. Update in: Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2209514119. doi: 10.1073/pnas.2209514119 PMID: 35702155 Free PMC article. Updated. Preprint.
Inherited nuclear pore substructures template post-mitotic pore assembly.
Chou YY, Upadhyayula S, Houser J, He K, Skillern W, Scanavachi G, Dang S, Sanyal A, Ohashi KG, Di Caprio G, Kreutzberger AJB, Vadakkan TJ, Kirchhausen T. Chou YY, et al. Dev Cell. 2021 Jun 21;56(12):1786-1803.e9. doi: 10.1016/j.devcel.2021.05.015. Epub 2021 Jun 14. Dev Cell. 2021. PMID: 34129835 Free PMC article.
31 results