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Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials.
Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Sinha P, et al. Lancet Respir Med. 2023 Nov;11(11):965-974. doi: 10.1016/S2213-2600(23)00237-0. Epub 2023 Aug 23. Lancet Respir Med. 2023. PMID: 37633303 Free PMC article.
Distinct immune profiles and clinical outcomes in sepsis subphenotypes based on temperature trajectories.
Bhavani SV, Spicer A, Sinha P, Malik A, Lopez-Espina C, Schmalz L, Watson GL, Bhargava A, Khan S, Urdiales D, Updike L, Dagan A, Davila H, Demarco C, Evans N, Gosai F, Iyer K, Kurtzman N, Palagiri AV, Sims M, Smith S, Syed A, Sarma D, Reddy B Jr, Verhoef PA, Churpek MM. Bhavani SV, et al. Intensive Care Med. 2024 Dec;50(12):2094-2104. doi: 10.1007/s00134-024-07669-0. Epub 2024 Oct 9. Intensive Care Med. 2024. PMID: 39382693
Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids.
Verhoef PA, Spicer AB, Lopez-Espina C, Bhargava A, Schmalz L, Sims MD, Palagiri AV, Iyer KV, Crisp MJ, Halalau A, Maddens N, Gosai F, Syed A, Azad S, Espinosa A, Davila F, Davila H, Evans NR, Smith S, Reddy B, Sinha P, Churpek MM. Verhoef PA, et al. Crit Care Med. 2023 Dec 1;51(12):1697-1705. doi: 10.1097/CCM.0000000000005983. Epub 2023 Jun 28. Crit Care Med. 2023. PMID: 37378460
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