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Small-molecule correctors and stabilizers to target p53.
Fallatah MMJ, Law FV, Chow WA, Kaiser P. Fallatah MMJ, et al. Trends Pharmacol Sci. 2023 May;44(5):274-289. doi: 10.1016/j.tips.2023.02.007. Epub 2023 Mar 22. Trends Pharmacol Sci. 2023. PMID: 36964053 Free PMC article. Review.
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins.
Fote GM, Eapen VV, Lim RG, Yu C, Salazar L, McClure NR, McKnight J, Nguyen TB, Heath MC, Lau AL, Villamil MA, Miramontes R, Kratter IH, Finkbeiner S, Reidling JC, Paulo JA, Kaiser P, Huang L, Housman DE, Thompson LM, Steffan JS. Fote GM, et al. Proc Natl Acad Sci U S A. 2024 Aug 6;121(32):e2319091121. doi: 10.1073/pnas.2319091121. Epub 2024 Jul 29. Proc Natl Acad Sci U S A. 2024. PMID: 39074279 Free PMC article.
Tryptophan metabolism is a physiological integrator regulating circadian rhythms.
Petrus P, Cervantes M, Samad M, Sato T, Chao A, Sato S, Koronowski KB, Park G, Alam Y, Mejhert N, Seldin MM, Monroy Kuhn JM, Dyar KA, Lutter D, Baldi P, Kaiser P, Jang C, Sassone-Corsi P. Petrus P, et al. Mol Metab. 2022 Oct;64:101556. doi: 10.1016/j.molmet.2022.101556. Epub 2022 Jul 29. Mol Metab. 2022. PMID: 35914650 Free PMC article.