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Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng L, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26. doi: 10.1021/jm901755g. J Med Chem. 2010. PMID: 20151671 Free PMC article.
VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling.
Mehta V, Fields L, Evans IM, Yamaji M, Pellet-Many C, Jones T, Mahmoud M, Zachary I. Mehta V, et al. Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1845-1858. doi: 10.1161/ATVBAHA.118.311118. Arterioscler Thromb Vasc Biol. 2018. PMID: 29880492 Free PMC article.