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Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity.
Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. Kulkarni RR, et al. J Virol. 2014 Dec;88(24):13990-4001. doi: 10.1128/JVI.02273-14. Epub 2014 Sep 24. J Virol. 2014. PMID: 25253340 Free PMC article.
The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.
Suthar MS, Ramos HJ, Brassil MM, Netland J, Chappell CP, Blahnik G, McMillan A, Diamond MS, Clark EA, Bevan MJ, Gale M Jr. Suthar MS, et al. Immunity. 2012 Aug 24;37(2):235-48. doi: 10.1016/j.immuni.2012.07.004. Epub 2012 Jul 26. Immunity. 2012. PMID: 22841161 Free PMC article.