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MIC-Drop: A platform for large-scale in vivo CRISPR screens.
Parvez S, Herdman C, Beerens M, Chakraborti K, Harmer ZP, Yeh JJ, MacRae CA, Yost HJ, Peterson RT. Parvez S, et al. Science. 2021 Sep 3;373(6559):1146-1151. doi: 10.1126/science.abi8870. Epub 2021 Aug 19. Science. 2021. PMID: 34413171 Free PMC article.
Intramuscular administration of glyoxylate rescues swine from lethal cyanide poisoning and ameliorates the biochemical sequalae of cyanide intoxication.
Bebarta VS, Shi X, Zheng S, Hendry-Hofer TB, Severance CC, Behymer MM, Boss GR, Mahon S, Brenner M, Knipp GT, Davisson VJ, Peterson RT, MacRae CA, Rutter J, Gerszten RE, Nath AK. Bebarta VS, et al. Toxicol Sci. 2023 Jan 31;191(1):90-105. doi: 10.1093/toxsci/kfac116. Toxicol Sci. 2023. PMID: 36326479 Free PMC article.
Glyoxylate protects against cyanide toxicity through metabolic modulation.
Nielson JR, Nath AK, Doane KP, Shi X, Lee J, Tippetts EG, Saha K, Morningstar J, Hicks KG, Chan A, Zhao Y, Kelly A, Hendry-Hofer TB, Witeof A, Sips PY, Mahon S, Bebarta VS, Davisson VJ, Boss GR, Rutter J, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Nielson JR, et al. Sci Rep. 2022 Mar 23;12(1):4982. doi: 10.1038/s41598-022-08803-y. Sci Rep. 2022. PMID: 35322094 Free PMC article.