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Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia.
Côté HC, Soudeyns H, Thorne A, Alimenti A, Lamarre V, Maan EJ, Sattha B, Singer J, Lapointe N, Money DM, Forbes J; CIHR Emerging Team in HIV therapy, aging (CARMA); Wong J, Bitnun A, Samson L, Brophy J, Burdge D, Pick N, van Schalkwyk J, Montaner J, Harris M, Janssen P. Côté HC, et al. PLoS One. 2012;7(7):e39266. doi: 10.1371/journal.pone.0039266. Epub 2012 Jul 16. PLoS One. 2012. PMID: 22815702 Free PMC article. Clinical Trial.
METHODS: In this cross-sectional CARMA cohort study, we investigated factors associated with LTL in HIV-1-infected (HIV(+)) children (n = 94), HIV-1-exposed uninfected (HEU) children who were exposed to antiretroviral therapy (ART) perinatally (n = 177 …
METHODS: In this cross-sectional CARMA cohort study, we investigated factors associated with LTL in HIV-1-infected (HIV(+)) ch …
Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy.
Zanet DL, Thorne A, Singer J, Maan EJ, Sattha B, Le Campion A, Soudeyns H, Pick N, Murray M, Money DM, Côté HC; CIHR Emerging Team Grant on HIV Therapy and Aging: CARMA. Zanet DL, et al. Clin Infect Dis. 2014 May;58(9):1322-32. doi: 10.1093/cid/ciu051. Epub 2014 Jan 22. Clin Infect Dis. 2014. PMID: 24457340
BACKGROUND: Individuals infected with human immunodeficiency virus (HIV) appear to age faster than the general population, possibly related to HIV infection, antiretroviral therapy, and/or social/environmental factors. ...In 2 models of HIV-infected in …
BACKGROUND: Individuals infected with human immunodeficiency virus (HIV) appear to age faster than the general population, possibly r …
Blood mitochondrial DNA mutations in HIV-infected women and their infants exposed to HAART during pregnancy.
Jitratkosol MH, Sattha B, Maan EJ, Gadawski I, Harrigan PR, Forbes JC, Alimenti A, van Schalkwyk J, Money DM, Côté HC; CIHR Emerging Team Grant on HIV Therapy and Aging (CARMA). Jitratkosol MH, et al. AIDS. 2012 Mar 27;26(6):675-83. doi: 10.1097/QAD.0b013e32835142eb. AIDS. 2012. PMID: 22436539
We hypothesized that HAART-exposed/HIV-uninfected infants may show higher blood mtDNA mutation burden than controls born to HIV-uninfected mothers. ...No difference was seen between control mothers and their infants (N = 39, both 17.9%). In HIV/HAART-exposed …
We hypothesized that HAART-exposed/HIV-uninfected infants may show higher blood mtDNA mutation burden than controls born to HIV …
Muscle power in children, youth and young adults who acquired HIV perinatally.
Macdonald ΗΜ, Nettlefold L, Maan EJ, Côté H, Alimenti A; CIHR Emerging Team Grant on HIV Therapy and Aging (CARMA). Macdonald ΗΜ, et al. J Musculoskelet Neuronal Interact. 2017 Jun 1;17(2):27-37. J Musculoskelet Neuronal Interact. 2017. PMID: 28574409 Free PMC article.
OBJECTIVES: To compare muscle power between youth who acquired HIV perinatally and HIV unexposed uninfected (HUU) youth. METHODS: We assessed muscle power (relative to body mass, P(max)/mass), muscle force normalized to body weight (F(max)/BW), force efficiency, jum …
OBJECTIVES: To compare muscle power between youth who acquired HIV perinatally and HIV unexposed uninfected (HUU) youth. METHO …
Leukocyte telomere length in HIV-infected pregnant women treated with antiretroviral drugs during pregnancy and their uninfected infants.
Imam T, Jitratkosol MH, Soudeyns H, Sattha B, Gadawski I, Maan E, Forbes JC, Alimenti A, Lapointe N, Lamarre V, Money DM, Côté HC; CIHR Emerging Team Grant on HIV Therapy and Aging: CARMA. Imam T, et al. J Acquir Immune Defic Syndr. 2012 Aug 15;60(5):495-502. doi: 10.1097/QAI.0b013e31825aa89c. J Acquir Immune Defic Syndr. 2012. PMID: 22580562
OBJECTIVES: HIV disease can lead to accelerated telomere attrition, although certain drugs used as part of antiretroviral therapy (ART) can inhibit telomerase reverse transcriptase activity. ...RESULTS: In HIV-infected ART-exposed mothers, leukocyte TL was no …
OBJECTIVES: HIV disease can lead to accelerated telomere attrition, although certain drugs used as part of antiretroviral therapy …
Bone geometry and strength are adapted to muscle force in children and adolescents perinatally infected with HIV.
Macdonald HM, Chu J, Nettlefold L, Maan EJ, Forbes JC, Côté H, Alimenti A; CIHR Emerging Team Grant on HIV Therapy and Aging (CARMA). Macdonald HM, et al. J Musculoskelet Neuronal Interact. 2013 Mar;13(1):53-65. J Musculoskelet Neuronal Interact. 2013. PMID: 23445915 Free article.
OBJECTIVES: To determine if bone health is compromised in perinatally HIV-infected youth. METHODS: We assessed BMC at the proximal femur, lumbar spine and total body using DXA in perinatally HIV-infected youth (n=31; 9-18y). ...In contrast, cortical BMD z-scores wer …
OBJECTIVES: To determine if bone health is compromised in perinatally HIV-infected youth. METHODS: We assessed BMC at the proximal fe …