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Long-term analysis of children with metastatic neuroblastoma treated in the ENSG5 randomised clinical trial.
Moreno L, Vaidya SJ, Schrey D, Pinkerton CR, Lewis IJ, Kearns PR, Machin D, Pearson ADJ; European Neuroblastoma Study Group and the Children's Cancer and Leukaemia Group (CCLG) (formerly UKCCSG). Moreno L, et al. Pediatr Blood Cancer. 2019 Apr;66(4):e27565. doi: 10.1002/pbc.27565. Epub 2018 Dec 5. Pediatr Blood Cancer. 2019. PMID: 30516328 Clinical Trial.
BACKGROUND: The European Neuroblastoma Study Group 5 (ENSG5) trial showed that time-intensive "rapid" induction chemotherapy (COJEC) was superior to "standard" 3-weekly chemotherapy for children with high-risk metastatic neuroblastoma. ...Amongst patients surviving …
BACKGROUND: The European Neuroblastoma Study Group 5 (ENSG5) trial showed that time-intensive "rapid" induction chemotherapy (COJEC) …
Long-term follow-up of children with high-risk neuroblastoma: the ENSG5 trial experience.
Moreno L, Vaidya SJ, Pinkerton CR, Lewis IJ, Imeson J, Machin D, Pearson AD; European Neuroblastoma Study Group; Children's Cancer and Leukaemia Group (CCLG) (formerly UKCCSG). Moreno L, et al. Pediatr Blood Cancer. 2013 Jul;60(7):1135-40. doi: 10.1002/pbc.24452. Epub 2012 Dec 31. Pediatr Blood Cancer. 2013. PMID: 23281263 Clinical Trial.
No differences were found in late toxicities between treatment arms. Twenty-eight children (49.1%) developed hearing loss. Nine patients (15.8%) developed glomerular filtration rate <80 ml/min/1.73 m(2), but no cases of chronic renal failure were documented. Endocrine c …
No differences were found in late toxicities between treatment arms. Twenty-eight children (49.1%) developed hearing loss. Nine patie …