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Year Number of Results
1891 1
1945 1
1946 7
1947 13
1948 19
1949 21
1950 104
1951 77
1952 149
1953 126
1954 172
1955 156
1956 186
1957 185
1958 185
1959 97
1960 56
1961 66
1962 103
1963 539
1964 755
1965 783
1966 740
1967 861
1968 979
1969 1053
1970 1041
1971 1098
1972 1249
1973 1052
1974 977
1975 1105
1976 1007
1977 949
1978 847
1979 838
1980 938
1981 766
1982 884
1983 813
1984 957
1985 900
1986 880
1987 839
1988 803
1989 906
1990 906
1991 893
1992 913
1993 896
1994 923
1995 969
1996 940
1997 1008
1998 992
1999 1065
2000 1017
2001 1119
2002 1140
2003 1158
2004 1225
2005 1336
2006 1233
2007 1321
2008 1415
2009 1433
2010 1469
2011 1559
2012 1683
2013 1872
2014 1849
2015 1836
2016 1873
2017 1878
2018 1944
2019 2072
2020 2213
2021 2343
2022 2373
2023 2266
2024 2261
2025 56

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73,325 results

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Page 1
NAD(+) homeostasis in human health and disease.
Zapata-Pérez R, Wanders RJA, van Karnebeek CDM, Houtkooper RH. Zapata-Pérez R, et al. EMBO Mol Med. 2021 Jul 7;13(7):e13943. doi: 10.15252/emmm.202113943. Epub 2021 May 27. EMBO Mol Med. 2021. PMID: 34041853 Free PMC article. Review.
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to other factors affecting NAD(+) homeostasis, such as increased NAD(+) consumption or dietary deficiency of its vitamin B3 precurso …
Primary deficiencies of NAD(+) homeostasis are the result of impaired biosynthesis, while secondary deficiencies can arise due to oth …
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.
Rajman L, Chwalek K, Sinclair DA. Rajman L, et al. Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. Cell Metab. 2018. PMID: 29514064 Free PMC article. Review.
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD(+) …
More recently, it has emerged as a signaling molecule. By modulating NAD(+)-sensing enzymes, NAD(+) controls hundreds of key p …
NAD metabolism: Role in senescence regulation and aging.
Chini CCS, Cordeiro HS, Tran NLK, Chini EN. Chini CCS, et al. Aging Cell. 2024 Jan;23(1):e13920. doi: 10.1111/acel.13920. Epub 2023 Jul 9. Aging Cell. 2024. PMID: 37424179 Free PMC article. Review.
Notably, the nucleotide nicotinamide adenine dinucleotide (NAD) interfaces with several biological hallmarks of aging, including cellular senescence, and changes in NAD metabolism have been shown to be involved in the aging process. ...Therefore, to explore the impl …
Notably, the nucleotide nicotinamide adenine dinucleotide (NAD) interfaces with several biological hallmarks of aging, including cell …
The kynurenine pathway: a finger in every pie.
Savitz J. Savitz J. Mol Psychiatry. 2020 Jan;25(1):131-147. doi: 10.1038/s41380-019-0414-4. Epub 2019 Apr 12. Mol Psychiatry. 2020. PMID: 30980044 Free PMC article. Review.
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the immune system. ...
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD …
NAD(+) Metabolism in Cardiac Health, Aging, and Disease.
Abdellatif M, Sedej S, Kroemer G. Abdellatif M, et al. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. Circulation. 2021. PMID: 34843394
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgenic overexpression of NAD(+)-generating enzymes have wide positive effects on metabolic health and age-associated diseases. ...Here, w …
Pharmacological or genetic inhibition of NAD(+)-degrading enzymes, external supplementation of NAD(+) precursors, and transgen …
Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns.
Bhasin S, Seals D, Migaud M, Musi N, Baur JA. Bhasin S, et al. Endocr Rev. 2023 Nov 9;44(6):1047-1073. doi: 10.1210/endrev/bnad019. Endocr Rev. 2023. PMID: 37364580 Review.
NAD+ levels decrease throughout life; age-related decline in NAD+ bioavailability has been postulated to be a contributor to many age-related diseases. ...Clinical pharmacology, metabolism, and therapeutic mechanisms of NAD+ precursors remain incompletely und …
NAD+ levels decrease throughout life; age-related decline in NAD+ bioavailability has been postulated to be a contributor to m …
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S. Pencina KM, et al. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1968-1980. doi: 10.1210/clinem/dgad027. J Clin Endocrinol Metab. 2023. PMID: 36740954 Free PMC article. Clinical Trial.
CONTEXT: Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related decline in NAD has been postulated to contribute to age-related diseases. ...These data provide the rationale for larger trials to assess the efficacy of NAD augmentati …
CONTEXT: Nicotinamide adenine dinucleotide (NAD) levels decline with aging and age-related decline in NAD has been postulated …
NAD(+)-Consuming Enzymes in Stem Cell Homeostasis.
Ji X, Zheng M, Yu T, Kang J, Fan T, Xu B. Ji X, et al. Oxid Med Cell Longev. 2023 Feb 8;2023:4985726. doi: 10.1155/2023/4985726. eCollection 2023. Oxid Med Cell Longev. 2023. PMID: 36819783 Free PMC article. Review.
NAD(+) is also required as a cofactor by nonredox NAD(+)-dependent enzymes. Hundreds of enzymes that consume NAD(+) have been identified. ...In this review, we discussed how different types of NAD(+)-consuming enzymes regulate SC functions and summariz …
NAD(+) is also required as a cofactor by nonredox NAD(+)-dependent enzymes. Hundreds of enzymes that consume NAD(+) hav …
NAD+-Increasing Strategies to Improve Cardiometabolic Health?
Blanco-Vaca F, Rotllan N, Canyelles M, Mauricio D, Escolà-Gil JC, Julve J. Blanco-Vaca F, et al. Front Endocrinol (Lausanne). 2022 Jan 31;12:815565. doi: 10.3389/fendo.2021.815565. eCollection 2021. Front Endocrinol (Lausanne). 2022. PMID: 35173682 Free PMC article. Review.
Depleted nicotinamide adenine dinucleotide (NAD+) is a common hallmark of metabolic disorders. Therefore, NAD+-increasing strategies have evolved as a potential therapeutic venue to combat cardiometabolic diseases. ...In this context, a major point of advancement in …
Depleted nicotinamide adenine dinucleotide (NAD+) is a common hallmark of metabolic disorders. Therefore, NAD+-increasing stra …
Genetically encoded probes for NAD(+)/NADH monitoring.
Bilan DS, Belousov VV. Bilan DS, et al. Free Radic Biol Med. 2016 Nov;100:32-42. doi: 10.1016/j.freeradbiomed.2016.06.018. Epub 2016 Jul 5. Free Radic Biol Med. 2016. PMID: 27387770 Review.
NAD(+) and NADH participate in many metabolic reactions. The NAD(+)/NADH ratio is an important parameter reflecting the general metabolic and redox state of different types of cells. For a long time, in situ and in vivo NAD(+)/NADH monitoring has been hampere …
NAD(+) and NADH participate in many metabolic reactions. The NAD(+)/NADH ratio is an important parameter reflecting the genera …
73,325 results
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