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Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
Segal EB, Tarquinio D, Miller I, Wheless JW, Dlugos D, Biton V, Cascino GD, Desai J, Hogan RE, Liow K, Sperling MR, Vazquez B, Cook DF, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group. Segal EB, et al. Epilepsia. 2021 Jun;62(6):1442-1450. doi: 10.1111/epi.16901. Epub 2021 May 4. Epilepsia. 2021. PMID: 33942315 Free PMC article. Clinical Trial.
Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy.
Wheless JW, Miller I, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group. Wheless JW, et al. Epilepsia. 2021 Oct;62(10):2485-2495. doi: 10.1111/epi.17041. Epub 2021 Aug 21. Epilepsia. 2021. PMID: 34418086 Free PMC article. Clinical Trial.
Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out-of-hospital seizure clusters: Results from a phase 3, open-label, repeat-dose safety study.
Sperling MR, Wheless JW, Hogan RE, Dlugos D, Cascino GD, Liow K, Rabinowicz AL, Carrazana E; DIAZ 001.05 Study Group. Sperling MR, et al. Epilepsia. 2022 Apr;63(4):836-843. doi: 10.1111/epi.17177. Epub 2022 Feb 2. Epilepsia. 2022. PMID: 35112342 Free PMC article. Clinical Trial.
Consistent safety and tolerability of Valtoco® (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long-term, open-label, repeat-dose safety study.
Miller I, Wheless JW, Hogan RE, Dlugos D, Biton V, Cascino GD, Sperling MR, Liow K, Vazquez B, Segal EB, Tarquinio D, Mauney W, Desai J, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group. Miller I, et al. Epilepsia Open. 2021 Sep;6(3):504-512. doi: 10.1002/epi4.12494. Epub 2021 May 13. Epilepsia Open. 2021. PMID: 34033266 Free PMC article. Clinical Trial.
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Liow K, Desai J, Davis C, Rabinowicz AL, Carrazana E; DIAZ.001.05 Study Group. Cascino GD, et al. Epilepsy Behav. 2021 Jul;120:107983. doi: 10.1016/j.yebeh.2021.107983. Epub 2021 May 3. Epilepsy Behav. 2021. PMID: 33957437 Free article. Clinical Trial.
Lack of clinically relevant differences in safety and pharmacokinetics after second-dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis.
Cascino GD, Tarquinio D, Wheless JW, Hogan RE, Sperling MR, Desai J, Vazquez B, Samara E, Misra SN, Carrazana E, Rabinowicz AL; DIAZ.001.05 Study Group. Cascino GD, et al. Epilepsia. 2022 Jul;63(7):1714-1723. doi: 10.1111/epi.17249. Epub 2022 Apr 19. Epilepsia. 2022. PMID: 35377464 Free PMC article.