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Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment.
de Jonge JC, Sluis WM, Reinink H, Bath PM, Woodhouse LJ, Zweedijk B, van de Beek D, Aamodt AH, Alpers I, Ciccone A, Csiba L, Demotes J, Kõrv J, Kurkowska-Jastrzebska I, Dawson J, Macleod MR, Ntaios G, Poli S, Milionis H, Ricci S, Cenciarelli S, Candelaresi P, de Bruijn SF, Pathansali R, Krishnan K, Clarke B, Thomalla G, van der Worp HB; PRECIOUS investigators. de Jonge JC, et al. Lancet Reg Health Eur. 2023 Dec 1;36:100782. doi: 10.1016/j.lanepe.2023.100782. eCollection 2024 Jan. Lancet Reg Health Eur. 2023. PMID: 38074444 Free PMC article.
Brain inflammation is induced by co-morbidities and risk factors for stroke.
Drake C, Boutin H, Jones MS, Denes A, McColl BW, Selvarajah JR, Hulme S, Georgiou RF, Hinz R, Gerhard A, Vail A, Prenant C, Julyan P, Maroy R, Brown G, Smigova A, Herholz K, Kassiou M, Crossman D, Francis S, Proctor SD, Russell JC, Hopkins SJ, Tyrrell PJ, Rothwell NJ, Allan SM. Drake C, et al. Among authors: selvarajah jr. Brain Behav Immun. 2011 Aug;25(6):1113-22. doi: 10.1016/j.bbi.2011.02.008. Epub 2011 Feb 26. Brain Behav Immun. 2011. PMID: 21356305 Free PMC article.
Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study.
Selvarajah JR, Smith CJ, Hulme S, Georgiou R, Sherrington C, Staniland J, Illingworth KJ, Jury F, Payton A, Ollier WE, Vail A, Rothwell NJ, Hopkins SJ, Tyrrell PJ. Selvarajah JR, et al. Int J Stroke. 2011 Jun;6(3):187-94. doi: 10.1111/j.1747-4949.2010.00561.x. Epub 2011 Jan 13. Int J Stroke. 2011. PMID: 21557802