Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae.
Chen Y, Wang L, Shang F, Liu W, Lan J, Chen J, Ha NC, Quan C, Nam KH, Xu Y.
Chen Y, et al.
Biochem Biophys Res Commun. 2019 Oct 20;518(3):513-518. doi: 10.1016/j.bbrc.2019.08.086. Epub 2019 Aug 19.
Biochem Biophys Res Commun. 2019.
PMID: 31439375
In bacterial thiamin synthesis and salvage pathways, the 5-(hydroxyethyl)-methylthiazole kinase (ThiM) is essential in the pathway forming TPP. Thus, ThiM is considered to be an attractive antibacterial drug target. ...The structures will provide new insight into th …
In bacterial thiamin synthesis and salvage pathways, the 5-(hydroxyethyl)-methylthiazole kinase (ThiM) is essential in the pathway fo …