Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis

Ann Neurol. 2012 May;71(5):601-13. doi: 10.1002/ana.22693. Epub 2012 Apr 4.

Abstract

Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large-scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon-glial interactions in those children destined for diagnosis of MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantigens / cerebrospinal fluid
  • Axons / metabolism*
  • Axons / pathology
  • Biomarkers / cerebrospinal fluid*
  • Child
  • Early Diagnosis
  • Female
  • Humans
  • Immunoblotting
  • Male
  • Mass Spectrometry
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / pathology
  • Myelin Proteins / cerebrospinal fluid
  • Nerve Tissue Proteins / cerebrospinal fluid*
  • Neuroglia / metabolism*
  • Neuroglia / pathology
  • Ranvier's Nodes / metabolism
  • Ranvier's Nodes / pathology

Substances

  • Autoantigens
  • Biomarkers
  • Myelin Proteins
  • Nerve Tissue Proteins